While there are no definitive diagnostic tests or FDA approved treatments specific to ME/CFS, there are no shortage of interventions a clinician can make to improve patient quality of life and significantly reduce the overall symptomatic burden of ME/CFS.
The following resources may assist with diagnosis of ME/CFS and provide guidance toward clinical management for those suffering from this illness.

Additional information is available on the Resources page

GETTING STARTED WITH THE BASICS

Medical providers can use the basic information on diagnosis and management in these resources to care for people with ME/CFS. Diagnosis involves positively identifying the key features of ME/CFS while also identifying alternative diagnoses that could fully explain the symptoms along with any comorbidities that are also present. Management starts with validating the patient’s experience and includes teaching them about pacing to minimize postexertional malaise, treating their symptoms and comorbidities, and helping them access needed support.

GUIDANCE ON DIAGNOSIS AND MANAGEMENT

The following resources provide more in-depth information about ME/CFS and its diagnosis and management in both adults and children. The first two resources are consensus recommendations from the ME/CFS Clinician Coalition on testing and treatment approaches. Other resources include adult and pediatric clinical primers authored by ME/CFS clinical experts from around the world and guidance for psychiatrists.

DIAGNOSING AND MANAGING KEY COMORBIDITIES

Patients with ME/CFS may experience a number of comorbidities. Treating these will not cure ME/CFS but can help decrease the symptom burden. The 2020 ME/CFS Clinician Coalition Handout on the Basics of Diagnosis and Treatment (referenced above) contains a list of the common comorbidities. The following resources provide clinical information on diagnosing and managing some of the key comorbidities seen in ME/CFS.

SPECIAL CONSIDERATIONS

People with ME/CFS who are severely ill, are pregnant, require emergency room services for acute illnesses, or who need to undergo surgery require special medical considerations. The 2014 IACFS/ME Primer, the 2012 ME-ICC Primer, and the 2017 Pediatric Primer contain general information on these topics. Additional information can be found in the following resources:

HELPING PATIENTS ACCESS DISABILITY AND ACCOMMODATIONS

People with ME/CFS often benefit from various support services, devices, and accommodations. Among these interventions are mobility and positional support devices, school accommodations, work accommodations, home health aids, and even disability resources or support. The following resources provide additional information on these topics: